PROTEIN C RESISTANCE IN PATIENTS WITH DEEP VEIN THROMBOSIS
AMINA MOHAMMED KHAIRY AHMED;
Abstract
1brombophilia is a tendency toward venous thromboembolic disease in adults under 50 years old in the absence of known risk factors including malignancy, immobilization, or major surgery.
Protein Cis a vitamin K-dependent plasma protein, that is activated
• to APC by thrombin-thrombomodulin complex, which is formed during the anticoagulant responses. APC functions as an anticoagulant by cleaving, and thus inactivating, factors Va and VIIIa, and protein S serves as a cofactor in this reaction.
1bree maJor groups of genetic defects contributing to thrombosis have now been identified; these correspond to mutations in components
of the protein C anticoagulant pathway, in antithrombin and in FV. The
-
identification of APC resistance, due to FV Leiden mutation, which is
a common genetic defect that prevents the inactivation of FVa by APC, has had a major impact on coagulation laboratory practice. Individuals with APC resistance have a sevenfold increase in risk of DVT, so it is the most important hereditary cause of venous thrombosis.
Protein Cis a vitamin K-dependent plasma protein, that is activated
• to APC by thrombin-thrombomodulin complex, which is formed during the anticoagulant responses. APC functions as an anticoagulant by cleaving, and thus inactivating, factors Va and VIIIa, and protein S serves as a cofactor in this reaction.
1bree maJor groups of genetic defects contributing to thrombosis have now been identified; these correspond to mutations in components
of the protein C anticoagulant pathway, in antithrombin and in FV. The
-
identification of APC resistance, due to FV Leiden mutation, which is
a common genetic defect that prevents the inactivation of FVa by APC, has had a major impact on coagulation laboratory practice. Individuals with APC resistance have a sevenfold increase in risk of DVT, so it is the most important hereditary cause of venous thrombosis.
Other data
| Title | PROTEIN C RESISTANCE IN PATIENTS WITH DEEP VEIN THROMBOSIS | Other Titles | مقاومة بروتين سى فى مرضى الجلطة الوريدية العميقة | Authors | AMINA MOHAMMED KHAIRY AHMED | Issue Date | 200 |
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