ROLE OF CD184 (CXCR4) AND CD26 IN ENGRAFTMENT POST HEMATOPOIETIC STEM CELL TRANSPLANTATION

Abstract

H ematopoietic stem cell transplantation is currently the standard therapy for many hematologic disorders and its use has markedly increased over the past two decades. Immune reconstitution is an important component of successful bone marrow transplantation since viral, fungal and bacterial infections contribute significantly to morbidity and mortality after engraftment. Many factors affecting immune reconstitution post-HSCT and successful engraftment. Enhancing engraftment and immune reconstitution post HSCT decrease the risk of graft failure and improve the survival post HSCT. We have studied the role of CD184 (CXCR4) and CD26 in engraftment in our prospective study which was held at Ain Shams University BMT unit between January 2012 and May 2014 with recruitment of 15 patients eligible for allo-HSCT and 15 patients eligible for auto-HSCT for diverse benign and malignant hematological disorders. Correlation between the level of CD184 in stem cell harvest, D28 and D90 post-transplantation and successful engraftment was achieved showing that there is a statistical significance between CXCR4 level in D90 post-transplant BM samples only and the occurance of successful engraftment with p-value = 0.002 and Associated criterion = ≤73.3 which means that successful engraftment is more likely in patients whose CD184 level in D90 BM sample is less than or equal to 73.3%.