Update on Role of Albumin in ICU
Ahmed Osman Abd El Kader;
Abstract
Albumin is an important molecule under physiological and pathophysiological conditions, with multiple effects, including regulation of osmotic pressure; carrier of poorly water soluble molecules ,such as hormones, cholesterol, calcium, iron, bilirubin, free fatty acids, and drugs; and anti-oxidant properties.
Human albumin (HA) is the most expensive non-blood plasma substitute used to treat hypovolaemia. HA is also used in many centres to correct hypoalbuminaemia. The role of HA is, however, still controversial and its use may be based more on custom than on a scientific basis. Because of its limited availability and high cost, it is imperative that the use of HA is restricted to indications for which it is efficacious. The arguments over its pros and cons are long-standing. Some meta-analyses that have tried to clarify the place of HA have resulted in widely divergent conclusion.
Albumin has been widely used in patients with cirrhosis in an attempt to improve circulatory and renal functions. The benefits of albumin infusions in preventing the deterioration in renal function associated with large-volume paracentesis, spontaneous bacterial peritonitis, and established hepatorenal syndrome in conjunction with a vasoconstrictor are well established.The recent development of the molecular adsorbent recirculating system, an albumin dialysis, is an example of the capacity of albumin to act by mechanisms other than its oncotic effect.
Albumin has neuroprotective properties. It appea
Human albumin (HA) is the most expensive non-blood plasma substitute used to treat hypovolaemia. HA is also used in many centres to correct hypoalbuminaemia. The role of HA is, however, still controversial and its use may be based more on custom than on a scientific basis. Because of its limited availability and high cost, it is imperative that the use of HA is restricted to indications for which it is efficacious. The arguments over its pros and cons are long-standing. Some meta-analyses that have tried to clarify the place of HA have resulted in widely divergent conclusion.
Albumin has been widely used in patients with cirrhosis in an attempt to improve circulatory and renal functions. The benefits of albumin infusions in preventing the deterioration in renal function associated with large-volume paracentesis, spontaneous bacterial peritonitis, and established hepatorenal syndrome in conjunction with a vasoconstrictor are well established.The recent development of the molecular adsorbent recirculating system, an albumin dialysis, is an example of the capacity of albumin to act by mechanisms other than its oncotic effect.
Albumin has neuroprotective properties. It appea
Other data
| Title | Update on Role of Albumin in ICU | Other Titles | تحديث عن دور الزلال في وحدة العناية المركزة | Authors | Ahmed Osman Abd El Kader | Issue Date | 2014 |
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