The Association between Helicobacter PyloriInfection and Insulin Resistance

Abstract

Helicobacter pylori is a helix-shaped Gram negative bacterium with 4-6 flagella.It produces catalase, and urease, oxidase. Helicobacter pyloriinfection is considered one of the most common chronic bacterial infections worldwide affecting large number of the general population in both developing and developed countries. Colonization with H.pyloriis not actually a disease but remian the relative risk of developing multiple clinical disorders of the upper gastrointestinal tract like (peptic ulcers ,chronic gastritis ,gastric adenocarcinoma & MALT lymphoma) and, possibly, may cause extragastric diseases like (Atherosclerotic heart disease, iron deficiency anemia, Immune thrombocytopenic purpura and others). The most common route of transmission of H.pylori is faeco-oral transmission. there are multiple methods of available to detect H.pylori infection including invasive methods based on gastric biopsies and noninvasive methods like serology, urea breath tests (UBTs), and stool antigen tests. Insulin resistance which is a pathologic state in which normal insulin concentrations produce a subnormal response in the peripheral tissues. This insulin resistance can progress to full Type 2 diabetes mellitus (T2DM). Insulin resistance results from multiple inherited and acquired causes. Hereditary causes like mutations of insulin receptor, glucose transporter, and signaling proteins, Acquired causes like physical inactivity, fatty diet and the aging process. Combinations of causes are common. There are several measures can be used to determine insulin resistance but The HOMA-IRmodel has proved to be an excellent clinical and epidemiological tool for the assessment of IR. The relationship between H.pylori infection and insulin resistance have shown in some studies but the sure association remain controversial. So, The aim of the present study is to search the relation between Helicobacter pylori infection and Insulin Resistance. The current study was conducted upon 80 patients complaining of dyspepsia recruited from gastroenterology and Hepatology unit, department of internal medicine, Ain Shams University hospital in the period from March 2016 to July 2016. Subjects were subdivided into two group; -a case group (A) including 40 patients with H.pylori positive diagnosed by histopathology. -a control group (B) including 40 patients with H.pylori negative diagnosed by histopathology.