Efficacy of Short-Term Low Dose Versus High Dose Statin in Preventing Contrast-Induced Nephropathy

Abstract

Background:A few studies focused on statin therapy as specific prophylactic measures of contrast-induced nephropathy have been published with conflicting results. In this prospective study we aimed to assess the effectiveness of short-term high-dose versus short term low – dose statin treatment for the prevention of CIN . Methods: A prospective study that includes 100 patient undergoing coronary angiography or percutanous coronary intervention at ( al galaa military hospital ) from Jan.2013 to June 2o13 . Patients were divided into 2 groups: Group A: includes fifty patients received low dose statin (10mg atorvastatin) one day before procedure. Group B: includes fifty patients received high dose statin (80mg atorvastatin) one day before procedure. Patients received 6 hours periprocedural hydration using 500 cc of normal saline , the dye used was Monomeric Low osmolar nonionic dye Iopromide (Ultravist ) Results were recorded using serum creatinine and glomerluar filtration rate before and after procedure . Results : CIN has been found in 32 % between group I while occurred in 16 % between group II, and this was statistically non significant with P value = 0.061 also mean level of serum creatinine in group I was lower than group II before and after administration of statin therapy with P value = 0.357 which is statistically non significant Conclusion :This study proved that there is no benefit of using short term statin ( high dose or low dose ) as a preventive measure of contrast induced nephropathy .