Immunohistochemical Study of the intra- hepatic (CD45RO) positive T-cellsin chronic Active Hepatitis and its Correlation With Stellate Cell Activation and Fibrogenesis

Abstract

Chronic active hepatitis is a major health problem in Egypt . Males are more commonly affected than females. Grade II /Ill activity are the most prevalent among Egyptian patients . Cirrhosis was present in more than 24% of the studied cases. A highly s)gnificant correlation exists between the grade of chronic hepatitis and the degree of CD 45 RO + ve immunostaining . Also the degree of stellate cell activation as detected by a smooth muscle actin immunostaining ,correlates well with the degree of fibrosis and the stage of the disease confirming the hypothesis that the greater the degree of necro­ inflammatory changes , the greater the degree of stellate cell activation and the greater the degree of fibrosis and the stage of the disease .