RENAL HANDLING OF CARNITINE IN PRETERM AND TERM NEONATES
Rehab Farouk Abu El Ela Haridi;
Abstract
Camitine is a quaternary ammonium compound synthesized in the body. It is an essential co-factor for transport oflong-chain fatty acids into mitochondria, where oxidation takes place. Premature infants have diminished renal proximal tubular function, and their ability to retain filtered camitine is impaired. The aim of this work is to study effect of prematurity and disease states on renal handling of camitine, and its consequences on the health of the new born.
The study was conducted on 36 neonates from NICU of children's Hospital, Ain-Shams University. They were subdivided into 3 groups:
Group I which included 12 preterrn healthy neonates, they were 7 males and 5 females, their gestational ages ranged from
29 to 35 weeks with a mean value of 31.3± 1.72 weeks. And Group II which included 14 preterm diseased neonates, they were 6 males and 8 females,. their gestational ages ranged from
28 -35 weeks with a mean value of 31.42± 2.40 weeks. The remaining 10 nom1al healthy fullterm neonates constitutes the
control group, and they were 4 males and 6 females, their gestational ages ranged from 38 to 41 weeks with a mean value of39.4±_0.96 weeks.
Cases and Controls were Subjected to:
History taking, thorough clinical examination, laboratory investigation including complete blood count, C-reactive Protein level, blood Culture and Sensitivity test only for diseased group, total Serum and Urinary Carnitine, serum and urinary creatinine, F1R ratio, urinary Proteins, glucose and
• phosphates I Creatinine ratio.
After Statistical Analysis O(The Results This Study Revealed
In our comparative study of the clinical data, we found a non-significant differences regarding age in both preterm health and diseased group versus control group, but a highly significant
The study was conducted on 36 neonates from NICU of children's Hospital, Ain-Shams University. They were subdivided into 3 groups:
Group I which included 12 preterrn healthy neonates, they were 7 males and 5 females, their gestational ages ranged from
29 to 35 weeks with a mean value of 31.3± 1.72 weeks. And Group II which included 14 preterm diseased neonates, they were 6 males and 8 females,. their gestational ages ranged from
28 -35 weeks with a mean value of 31.42± 2.40 weeks. The remaining 10 nom1al healthy fullterm neonates constitutes the
control group, and they were 4 males and 6 females, their gestational ages ranged from 38 to 41 weeks with a mean value of39.4±_0.96 weeks.
Cases and Controls were Subjected to:
History taking, thorough clinical examination, laboratory investigation including complete blood count, C-reactive Protein level, blood Culture and Sensitivity test only for diseased group, total Serum and Urinary Carnitine, serum and urinary creatinine, F1R ratio, urinary Proteins, glucose and
• phosphates I Creatinine ratio.
After Statistical Analysis O(The Results This Study Revealed
In our comparative study of the clinical data, we found a non-significant differences regarding age in both preterm health and diseased group versus control group, but a highly significant
Other data
| Title | RENAL HANDLING OF CARNITINE IN PRETERM AND TERM NEONATES | Other Titles | تعامل الكلى مع الكارنتين فى حديثي الولادة الطبيعيين والمبتسرين | Authors | Rehab Farouk Abu El Ela Haridi | Issue Date | 2001 |
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