SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW FUROCHROMONE AND BENZOFURAN DERIVATIVES\

Abstract

The increasing chemothrapeutic properties of visnagin and benzofuran derivatives led us to synthesize some new sulfonamide derivatives in a trial to obtain much more potent products with more biological activity than the parent compounds.

To start with, visnagin-9-sulfonarnide derivatives were condensed with aromatic aldehydes to give visnagin-7-styryl-9-sulfonamide derivatives for the purpose of evaluating their antimicrobial activity.

The introduction of heterocyclic ring system (1,2,3- thia and selenadiazol-4-yl) through the sulfonamide linkage at 9-position of visnagin was achieved to evaluate antimicrobial activity of the newly produced compounds.

Moreover, the action of alkali (3% KOH ) or hydrazine hydrate on visnagin-9-sulfonamide derivatives were studied in order to obtain new compounds with higher biological activity.

The whole work including the synthesis and biological eval-

uation of the new visnagin derivatives is presented in two parts, the chemical and biological parts.

main

I-The chemical part:

This part is presented in the following two sections:

1:1-Synthesis of some visnagin-7-(substituted styryl) 9- sulfonamide derivatives:

Condensation of aromatic aldehydes, namely, benzaldehyde, p-chlorobenzaldehyde or p-riitrobenzaldehyde with the key inter­ mediates, visnagin-9-sulfonarnide derivatives ( XXXIIa-c and CVII) Scheme 1 ), and in the presence of sodium ethoxide led to