MOLECULAR AND SEROLOGIC DIAGNOSIS OF DENGUE VIRUS
Eiman Ahmad Salama Elbishbishi;
Abstract
Viruses are the smallest infectious agents (20-300 mn in diameter), containing only one kind ofm1cleic acid (RNA or Dr\ A) as their genome.
The nucleic acid is encased in a protein shell, which may be surrounded by a lipid-containing nvelope. The entire infectious unit IS tenned a virion. Viruses replicate only in li1•ing cells. being parasites at the genetic level. The viral nucleic acid contains infonnation necessary for programmmg the infected host cell to synthesize a number of 1•irus-specific macromolecules required for the production of viral progeny.
During the replicative cycle. numerous copies 6f viral nucleic acid and coat proteins are produced. The coat proteins assemble together to fonn the capsid, which encases and stabilizes the viral nucleic acid against the extracellular environment and facilitates the attachment and perhaps penetration by the virus upon contact with new susceptible cells (Melnick
1995)
The nucleic acid is encased in a protein shell, which may be surrounded by a lipid-containing nvelope. The entire infectious unit IS tenned a virion. Viruses replicate only in li1•ing cells. being parasites at the genetic level. The viral nucleic acid contains infonnation necessary for programmmg the infected host cell to synthesize a number of 1•irus-specific macromolecules required for the production of viral progeny.
During the replicative cycle. numerous copies 6f viral nucleic acid and coat proteins are produced. The coat proteins assemble together to fonn the capsid, which encases and stabilizes the viral nucleic acid against the extracellular environment and facilitates the attachment and perhaps penetration by the virus upon contact with new susceptible cells (Melnick
1995)
Other data
| Title | MOLECULAR AND SEROLOGIC DIAGNOSIS OF DENGUE VIRUS | Other Titles | التشخيص الفيرولوجي والجزيئي لفيروس الضنك | Authors | Eiman Ahmad Salama Elbishbishi | Issue Date | 2000 |
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