Effect of Active H. pylori Infection on Persistence and Chronicity of ITP in Children & Adolescents
Samuel Noshy Azer Beshay;
Abstract
SUMMARY AND CONCLUSION
H
elicobacter pylori and immune thrombocytopenic purpura (ITP) association is not well established in chronic ITP (cITP) in children, although the cure of thrombocytopenia in approximately half of H. pylori eradicated adult patients has been described.
The aim of this study was to investigate the prevalence of H. pylori infection among children and adolescents with persistent and chronic ITP through a cross-sectional study. A total of forty children (mean age 8.5 years) were enrolled in the study, including nineteen female (47.5%) and twenty-one males (52.5%), 10 of them with having persistent ITP (35%) and 30 patients with chronic ITP (75%).
Diagnosis of H. pylori was established by two locally validated tests, 13C-urea breath test and H. pylori antibodies (IgA and IgG).
The study population was categorized according to pattern of platelets, since diagnosis with ITP till time of enrollment in the current study, into those with steady pattern of platelets (n= 21) and those with unsteady pattern of platelets (n= 19). At baseline, there were no differences regarding age, gender, duration of disease, SMOG score and DGSS.
The prevalence of H. pylori infection in pediatric ITP in this study was found to be 32.5%. Cytotoxin associated gene A and vacuolating cytotoxin gene A IgG antibodies were present in six out of seven infected patients.
Since the prevalence of H. pylori infection in Egyptian children with persistent and chronic ITP was not higher than that found in the general population, so we can conclude that H. pylori infection may not play a causative role in childhood chronic ITP.
H
elicobacter pylori and immune thrombocytopenic purpura (ITP) association is not well established in chronic ITP (cITP) in children, although the cure of thrombocytopenia in approximately half of H. pylori eradicated adult patients has been described.
The aim of this study was to investigate the prevalence of H. pylori infection among children and adolescents with persistent and chronic ITP through a cross-sectional study. A total of forty children (mean age 8.5 years) were enrolled in the study, including nineteen female (47.5%) and twenty-one males (52.5%), 10 of them with having persistent ITP (35%) and 30 patients with chronic ITP (75%).
Diagnosis of H. pylori was established by two locally validated tests, 13C-urea breath test and H. pylori antibodies (IgA and IgG).
The study population was categorized according to pattern of platelets, since diagnosis with ITP till time of enrollment in the current study, into those with steady pattern of platelets (n= 21) and those with unsteady pattern of platelets (n= 19). At baseline, there were no differences regarding age, gender, duration of disease, SMOG score and DGSS.
The prevalence of H. pylori infection in pediatric ITP in this study was found to be 32.5%. Cytotoxin associated gene A and vacuolating cytotoxin gene A IgG antibodies were present in six out of seven infected patients.
Since the prevalence of H. pylori infection in Egyptian children with persistent and chronic ITP was not higher than that found in the general population, so we can conclude that H. pylori infection may not play a causative role in childhood chronic ITP.
Other data
| Title | Effect of Active H. pylori Infection on Persistence and Chronicity of ITP in Children & Adolescents | Other Titles | الإصابة النشطة للبكتريا الحلزونية وتاثيرها على مرض نقص الصفائح الدموية المستديم و المزمن لدى الأطفال والمراهقين | Authors | Samuel Noshy Azer Beshay | Issue Date | 2017 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.