Inherited Thrombophilia in Paediatric Ischemic Stroke

Abstract

Pediatric ischemic stroke represents a burden, and more than half of the survivors will experience cognitive or motor disabilities. Ischemic stroke in children is multifactorial. Congenital and acquired prothrombotic disorders have been highlighted in a recent series of pediatric stroke, with a controversial role in pathogenesis. Thrombophilia testing should be performed in any child with ischemic stroke (Haywood et al. 2005; Muwakkit et al. 2011; Shatla et al. 2012; Eltayeb et al. 2015). In the current study, we aimed at exploring the risk factors, clinical features, and neuroimaging findings and to investigate the role of thrombophilia mutations in a cohort of children with arterial ischemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT). The current study was conducted on 31 pediatric patients consecutively referred to the pediatric emergency room or pediatric neurology outpatient clinic of Ain Shams University with clinical and neuroimaging evidences of stroke over a period of 18 months fr