Utilization of some furanone derivatives for the construction of other heterocyclic systems
Sayed Karam Ramadan Emam Dahroug;
Abstract
Among heterocyclic compounds, 2(3H)-furanones represent an
important type of five-membered heterocyclic systems. The
importance of these compounds stems from the facile opening of the
lactone ring with both nucleophilic and electrophilic reagents to give
acyclic products. These acyclic products are the precursors of a wide
variety of synthetically and biologically important heterocycles viz.
pyrrolone, triazole, benzoxazinone, pyridazinone, thiazolidinone,
quinolone and oxadiazole derivatives.
In this investigation, the author wishes to report on the behavior
of 2(3H)-furanone derivatives towards some nucleophiles aiming to
construct several heterocycles, to evaluate their biological activities
e.g. antitumor & antimicrobial activities, and as alkylating agents.
The original work of this thesis consists of four parts:
Part I:
This part discusses the reactions of pyrazolyl-2(3H)-furanone 1
with different nitrogen nucleophiles e.g. ammonia, hydrazine
hydrate, benzylamine and anthranilic acid to afford pyrrolone 2,
hydrazide 3, N-benzylamide 4 and benzoxazinone 5 derivatives. The
important type of five-membered heterocyclic systems. The
importance of these compounds stems from the facile opening of the
lactone ring with both nucleophilic and electrophilic reagents to give
acyclic products. These acyclic products are the precursors of a wide
variety of synthetically and biologically important heterocycles viz.
pyrrolone, triazole, benzoxazinone, pyridazinone, thiazolidinone,
quinolone and oxadiazole derivatives.
In this investigation, the author wishes to report on the behavior
of 2(3H)-furanone derivatives towards some nucleophiles aiming to
construct several heterocycles, to evaluate their biological activities
e.g. antitumor & antimicrobial activities, and as alkylating agents.
The original work of this thesis consists of four parts:
Part I:
This part discusses the reactions of pyrazolyl-2(3H)-furanone 1
with different nitrogen nucleophiles e.g. ammonia, hydrazine
hydrate, benzylamine and anthranilic acid to afford pyrrolone 2,
hydrazide 3, N-benzylamide 4 and benzoxazinone 5 derivatives. The
Other data
| Title | Utilization of some furanone derivatives for the construction of other heterocyclic systems | Other Titles | استخدام بعض مشتقات الفيورانون لبناء انظمة اخرى غير متجانسة الحلقات | Authors | Sayed Karam Ramadan Emam Dahroug | Issue Date | 2017 |
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