ROLE OF CT PERFUSION IN ADULT BRAIN TUMORS (Diagnosis, grading and follow up)

Abstract

Gliomas, the most common primary brain neoplasms inadults, are very heterogeneous tumors. High-grade gliomas can be highly invasive and extremely vascular tumors. Two of the most important factors in determining the malignancy of gliomas are their ability to infiltrate the brain parenchyma and to recruit or synthesize vascular networks for further growth (ie, neoangiogenesis) CT Perfusion is a technique that can be readily incorporated into the existing CT protocols to provide an in vivo marker of tumour angiogenesis. By capturing physiological information reflecting the tumour vasculature, perfusion CT can be useful for diagnosis and therapeutic monitoring. In the current study there were significant differences in perfusion parameters between low and high grade tumor This parameteric differentiation was demonstrated in our study with great sensitivity and specificity. And according to these results, CT perfusion may be of great clinical use in differentiate between low and high grade tumor Also CT perfusion can differentiate between the residual malignant remnants from the necrotic / radiotherapy effect At our study we found the blood volume and permeability surface are the most sensitive CT perfusion parameter rather than blood flow