Recombinant Human Granulocytes Colony Stimulating Factor, (G-CSF) and Intravenous Immunoglobulin (IVIG) Administration in Newborn Infants with Late Onset Sepsis

Abstract

Neonatal sepsis Is one of the major problems that meet the pediatrician. Saving life in these critically patients is of practical importance, we cannot put the expenses of the treatment in the face of saving their life. In our piecework we have thro"Nn the light on the different lines used in management, proper antibiotics, G-CSF, G-CSF plus IVIG. We tried in 60 septic neonates with late onset neonatal sepsis irrespective to their neutrophilic count, one third were given the standard antibiotic therapy, other one third were given G-CSF in addition to the standard antibiotic therapy, and the remaining third were given G-CSF and IVIG plus the standard antibiotic therapy. Once diagnosis of sepsis is suspected by a thorough history taking, clinically by having a clinical scoring system of 3 or more, and hematological score 3 or more, sepsis work up is done (blood culture, CSF culture, etc) and each neonate was randomly fallen into a specific group and started antibiotic therapy. In addition, either G-CSF in a dose of 10 meg/kg/kg subcutaneously for 3 successive days. Or G-CSF plus IVIG in a dose of 500 mg /kg/once intravenously was given, and cases with negative blood culture were excluded. Blood culture was positive in 100% of cases of suspected sepsis, and the most common•• causative organism was klebsiella (43%), followed by Staph. aureus (23.3%), then E.Coli (16.7%).