Updating Microanalytical Methods for the Determination of Some Heterocyclic Compounds

Abstract

The present work is focused on developing novel electrochemical sensors based on potentiometric transduction mode .pyrimethamine, domperidone and ramipril liquid polymeric sensors based on ion exchangers are developed and characterized . Characterization studies are carried out according to IUPAC recommendations. The three electroactive materials used in chapter II are pyrimethamine tetraphenylborate,pyrimethamine phosphomolibdate and pyrimethamine phosphotungestate. Tetraphenyleborate and phosphomolybdaic acid was used as the counter ion in chapter III and IV concerning domperidone and ramipril respectively. The performance of the sensors are optimized for pyrimethamine,domperidone and ramipril quantification in pure samples and in their pharmaceutical formulations. The high recovery percentage and low relative standard deviation reflect the high accuracy and precision of the proposed method, moreover, the method is easy applicable to a wide range of concentration, besides being less time consuming