Outcome of Childhood Hematologic Malignancies in Ain Shams University Hospital: A Ten-Year Retrospective Study

Abstract

Background: Hematopoietic neoplasms constitute more than 40% of malignancies in children and represent a wide range of disorders that include acut leukemias and lymphomas. Aim: We aimed to evaluate outcome of children with hematologic malignancies in Ain Shams University at Pediatric Oncology clinic with the use of the currant treatment protocols and assess the need for a more risk based adapted therapy. Methods: 194 patients with ALL, 42 with AML, 65 with NHL, and 29 HL patients, registered at Pediatric Oncology Clinic, Ain Shams University Children’s Hospital from January 2005 through December 2014, were included in the study. ALL patients were treated according to a modified CCG 1991 and 1961 for standard and high risk respectively. Patients were stratified into 3 risk groups. SR, HR-SA and HR-AA. AML patients were treated according to a modified MRC based protocol, they included 3 risk groups, favorable, intermediate and high. NHL was classified into lymphoblastic lymphoma, mature B-NHL and anaplastic large cell lymphoma, and treated according to BFM protocols for the different entities. HL patients were stratified into 3 risk groups; low, intermediate and high, and were treated according to the ABVD regimen and. Results: For ALL patients, the mean age at diagnosis was 6.1±3.9 years, male: female ratio 1.3:1. The 10-year OS was 85.3% while the 10-year EFS was 80.4%. Pre-B patients had significantly better outcome than T-cell patients (OS 88.8% and 68.6%, P=0.001; EFS 83.2% and 66.7%, P=0.015 for pre-B and