A STUDY OF THE ROLE OF ENDOTHELIN-1 IN THE PATHOGENESIS OF PEPTIC ULCER IN PATIENTS WITH LIVER CIRRHOSIS AND RENAL FAILURE
Tarek Ahmed Talat El-Sharawy;
Abstract
Peptic ulcer in the human stomach causes localised destruction of the gastric wall, which may be associated with focal vascular insufficiency. E:ndothelin-1(ET-1) , is an extremely potent vasoconistrictor peptide, which is mainly drived from vascular endothelial cells and modulates regional blood flow in the vasculature of stomach.
We have studied the role of ET-1 in the human peptic ulcer
'
in conditions associated with disturbances :of endogenous
homeostasis, to demonestrate its effect in various disorders.
'. The study was carried out on 55 patients ,in addition to 5 healthy persons as controls, they were classified into six groups.
Group 1: 15 patients with peptic ulcer only.
Group II: 10 cirrhotic patients who were not suffuring from peptic ulcer.
Group III: 10 drrhotic patients with active peptic ulcer.
Group IV: 10 patients with CRF only and are not suffuring from peptic ulcer.
Group v: 10 patients with CRF and active peptic ulcer.
Control Group: 5 healthy persons with non ulcer dyspepsia
We have studied the role of ET-1 in the human peptic ulcer
'
in conditions associated with disturbances :of endogenous
homeostasis, to demonestrate its effect in various disorders.
'. The study was carried out on 55 patients ,in addition to 5 healthy persons as controls, they were classified into six groups.
Group 1: 15 patients with peptic ulcer only.
Group II: 10 cirrhotic patients who were not suffuring from peptic ulcer.
Group III: 10 drrhotic patients with active peptic ulcer.
Group IV: 10 patients with CRF only and are not suffuring from peptic ulcer.
Group v: 10 patients with CRF and active peptic ulcer.
Control Group: 5 healthy persons with non ulcer dyspepsia
Other data
| Title | A STUDY OF THE ROLE OF ENDOTHELIN-1 IN THE PATHOGENESIS OF PEPTIC ULCER IN PATIENTS WITH LIVER CIRRHOSIS AND RENAL FAILURE | Other Titles | دراسة دور الإندوثيلين -1 فى حدوث قرحة المعدة فى مرضى التليف الكبدى والفشل الكلوى | Authors | Tarek Ahmed Talat El-Sharawy | Issue Date | 2002 |
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