Role of Zinc in I.C.U Patients
Sherif Mohammed Khalifa El-Kattan;
Abstract
Zinc is an important factor in homeostasis, allowing the efficient handling of an excess of orally ingested zinc, because after intraperitoneal injection into mice, the LD50 for zinc was only approximately four-fold higher than for cadmium and mercury.
In contrast to the other two metals, for which no role in human physiology is known, zinc is an essential trace element not only for humans, but for all organisms. It is a component of more than 300 enzymes and an even greater number of other proteins, which emphasizes its indispensable role for human health.
Zinc homeostasis is tightly controlled by three mechanisms: (A) Transport through the plasma membrane by zinc transporters from the ZnT (SLC A30) or ZIP (SLC A39) families. (B) Buffering by metallothionein. (C) Reversible transport by ZnT and ZIP proteins into or out of zincosomes.
There are three major routes of entry for zinc into the human body; by inhalation, through the skin, or by ingestion.
The most widely known effect of inhaling zinc-containing smoke is the so-called metal fume fever (MFF), which is mainly caused by inhalation of zinc oxide.
The gastrointestinal tract is directly affected by ingested zinc, before it is distributed through the body leading to development of gastroduodenal corrosive injury. Whereas several other metals are well-known carcinogens, zinc is not generally considered to be a causative agent for cancer development. Sufficient availability of zinc is of particular importance to the immune system. Thereby, it plays a key role in multisided cellular and molecular mechanisms
In contrast to the other two metals, for which no role in human physiology is known, zinc is an essential trace element not only for humans, but for all organisms. It is a component of more than 300 enzymes and an even greater number of other proteins, which emphasizes its indispensable role for human health.
Zinc homeostasis is tightly controlled by three mechanisms: (A) Transport through the plasma membrane by zinc transporters from the ZnT (SLC A30) or ZIP (SLC A39) families. (B) Buffering by metallothionein. (C) Reversible transport by ZnT and ZIP proteins into or out of zincosomes.
There are three major routes of entry for zinc into the human body; by inhalation, through the skin, or by ingestion.
The most widely known effect of inhaling zinc-containing smoke is the so-called metal fume fever (MFF), which is mainly caused by inhalation of zinc oxide.
The gastrointestinal tract is directly affected by ingested zinc, before it is distributed through the body leading to development of gastroduodenal corrosive injury. Whereas several other metals are well-known carcinogens, zinc is not generally considered to be a causative agent for cancer development. Sufficient availability of zinc is of particular importance to the immune system. Thereby, it plays a key role in multisided cellular and molecular mechanisms
Other data
| Title | Role of Zinc in I.C.U Patients | Other Titles | دور عنصر الزنك فى مرضى الرعاية الطبية الحرجة | Authors | Sherif Mohammed Khalifa El-Kattan | Issue Date | 2015 |
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