The Role of Poisoning Severity Score, QTc Interval and Some Biomarkers in Assessment of The Severity of Organophosphorus Compound Acutely Intoxicated Cases Admitted to Poison Control Center Ain Shams University

Abstract

Poisoning with OP compounds is responsible for great morbidities and mortalities all over the world especially in developing countries including Egypt. There are no validated scoring systems for categorizing severity or predicting the outcome of acute OP poisoning.The highly variable history and difficulty in determining the dose and specific OP compound ingested make predicting outcome for an individual person inaccurate and potentially hazardous. Patients admitted in good condition can deteriorate rapidly and may require intubation and mechanical ventilation. This work aimed to study the role of the some indices that may help in the assessment of the severity and outcome of acutely organophosphorus (OP) intoxicated cases. These indices include; poison severity score (PSS), corrected QT interval (QTc), Creatine phosphokinase (CPK), Lactate dehydrogenase (LDH), C- reactive protein (CRP) and difference in C-reactive protein (D-CRP) value between initial and after 24 hours. This work presents a cross sectional study carried out at Poison Control Center Ain Shams University (PCCASU). The study included one hundred acutely organophosphorus intoxicated patients. They were selected according to predetermined criteria.