Utility of some Arylidenes of Active Methylene Compounds in Heterocyclic Synthesis
Safaa Maher Abdo Haroun;
Abstract
This work illustrates the versatile role of activated
nitriles in the synthesis of different heterocyclic systems.
The arylidenes of active methylene compounds 1a-c
were allowed to react with different nucleophiles such as
thioglycolic acid, barbituric acid and thiourea to give 7Hthiazolo[
3,2-a]pyridine derivatives 2a-c, the pyridinium salt
3 and 6-amino-4-(4-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-
5-carbonitrile (4) respectively [cf. scheme
nitriles in the synthesis of different heterocyclic systems.
The arylidenes of active methylene compounds 1a-c
were allowed to react with different nucleophiles such as
thioglycolic acid, barbituric acid and thiourea to give 7Hthiazolo[
3,2-a]pyridine derivatives 2a-c, the pyridinium salt
3 and 6-amino-4-(4-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-
5-carbonitrile (4) respectively [cf. scheme
Other data
| Title | Utility of some Arylidenes of Active Methylene Compounds in Heterocyclic Synthesis | Other Titles | استخدما بعض الأريليدينات لمركبات حاوية على مجموعة مثيلين نشطة فى تشييد مركبات غير متجانسة الحلقة | Authors | Safaa Maher Abdo Haroun | Issue Date | 2014 |
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