AMELIORATION OF RADIATION INDUCED BIOCHEMICAL DISORDERS IN RATS USING SOME ANABOLIC AND ANTI-INFLAMMATORY DRUGS
Nashwa Kamel Ibrahim Solim a n;
Abstract
The expanding use of nuclear power and IOlliZing radiation i;• various fields of biological and life sciences put to the forefront the search for ways of improving the radioresistance of such biological systems including man against radiation hazards and sickness.
One of the real possibilities increasing the radioresistance of animal body is the use of pharmacological and chemical means. Pharmacological protection is meant the introduction of a protector into an organism prior to irradiation to improve the survival of animals.
The problem of chemical radiation protection 1s being studied intensively, however, the practical application of protectors especially anti intlar•..natory and anabolic drugs encounters a number of difficulties associated both with the features of compounds. mode of action within irradiated biological systems. Therefore, investigations in this field al so deep n our understanding of the essence of the biological action ofionizin t;
-radiation.
The aim of the present study is to explore the possible effect of some anti-inflammatory drug such as Piroxicam (Feldene) and Tiaprofenic acid (Surgam) and anabolic drug known as Nandrolone Decanoate
:oecaduraboline) against the biological disorders induced in experimental
:mimals due to the exposure to ionizing radiation at a dose level of 6 Gy.
280 male albino rats (Rattus norvegicus) with body weight of I 00 - 120g
Nere used in the current experiments.
One of the real possibilities increasing the radioresistance of animal body is the use of pharmacological and chemical means. Pharmacological protection is meant the introduction of a protector into an organism prior to irradiation to improve the survival of animals.
The problem of chemical radiation protection 1s being studied intensively, however, the practical application of protectors especially anti intlar•..natory and anabolic drugs encounters a number of difficulties associated both with the features of compounds. mode of action within irradiated biological systems. Therefore, investigations in this field al so deep n our understanding of the essence of the biological action ofionizin t;
-radiation.
The aim of the present study is to explore the possible effect of some anti-inflammatory drug such as Piroxicam (Feldene) and Tiaprofenic acid (Surgam) and anabolic drug known as Nandrolone Decanoate
:oecaduraboline) against the biological disorders induced in experimental
:mimals due to the exposure to ionizing radiation at a dose level of 6 Gy.
280 male albino rats (Rattus norvegicus) with body weight of I 00 - 120g
Nere used in the current experiments.
Other data
| Title | AMELIORATION OF RADIATION INDUCED BIOCHEMICAL DISORDERS IN RATS USING SOME ANABOLIC AND ANTI-INFLAMMATORY DRUGS | Other Titles | تحسين بعض الاختلالات الكيموحيوية المحدثة بالاشعاع فى فئران التجارب باستخدام بعض العقاقير البناءة والمضادة للالتهاب | Authors | Nashwa Kamel Ibrahim Solim a n | Issue Date | 2000 |
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