. ACUTE PHASE PROTEINS IN DEPRESSION

Abstract

\ . I. fr I . I evressJOn 1s among t 1e most equent y occurnng or preva ent . I psychiatric disorders in adults. There are estimates that at least one

•.Recent I

s in psychoneuroimmunology suggest that

hundred millihn people are suffering from depressive disorders. development

major depression and stressful life events may modify immune functions. It \is hypothesized that increased IL. production in major depression may constitute a common denominator for alteration in positive and r\egative APPs. The genetic contribution to depression is one of the best established aetiological clues for this common and . . d .. senous con rtron.

The aim\ of this study was to evaluate and compare changes in some APPs including (Hp, C3c, Alb and Tf) in depression, schizophrenia and mania as lell as to determine Tf polymorphism as a genetic marker in depression. In order to achieve these goais, 220 subjects were included; I 00 healthy persons (control group) matching the patient groups in age anCl sex. 120 diseased subjects (patient groups) who further '"bdi'' ''"'"' I'00 "'"'"""• I o <ehiwt'"''"';,'""' l<t "'"";,'""''"', Estimations of their serum Hp, C3c and Tf levels were performed by single radial\immunodiffusion plates and Alb level was estimated by bromocresol grlen method while Tf polymorphism was done using ultrathin layer polfacrylamid gel isoelectric focusing