Effect of Application of Different Scaffolds on the Revascularization Potentials of Mature Teeth with Chronic Apical Periodontitis

Abstract

The aim of this study was to assess the regenerative potential of mature teeth with chronic apical periodontitis histomorphometrically and immunologically. Alternative combinations of ciprofloxacin, DAP and TAP with and without collagen membrane and gelfoam scaffolds were used. Eighteen dogs aged 10 months were selected. Three lower premolars were chosen from each one of them. This corresponded to a total of 96 roots. Groups were allocated as into six experimental groups and two control groups, each group included 12 roots as follows: 1. Ciprofloxacin/Collagen 2. DAP/Collagen 3. TAP/Collagen 4. Ciprofloxacin/Gelfoam 5. DAP/ Gelfoam 6. TAP/Gelfoam Controls included a positive group and a negative one where infected untreated and normal untouched teeth were respectively allocated.

Teeth were accessed and infection induced into root canals for one month, lesions were radiographically confirmed. Canal disinfection with antibiotics was carried out for one more month, then bleeding induction and scaffold placement with an MTA orifice plug and glass ionomer coronal seal were