Utility of Hydrazines in The Synthesis of Some Heterocycles

Abstract

Derivatives of thiosemicarbazide are a class of organic compounds that were found to be associated with various biological activities . They are known to exhibit antifungal , anti-inflammatory, anti HIV and herbicidal activities . Moreover, they are used as corrosion inhibitors of steal and semiconductors , in addition to their uses in the metal complexes . Thiosemicarbazides are versatile compounds, which have been extensively used in the synthesis of different heterocyclic ring systems . The original work of this thesis can be classified into three parts:

Part 1: In this part, the synthesis of acyl thiosemicarbazides 1-(2-Benzamido- 3-arylacryloyl)-4-dodecanoyl thiosemicarbazides and 1-(2- benzamido-3-arylacryloyl)-4-phenyl- thiosemicarbazide and their cyclization with different reagents in different media are described. Part 2: The antimicrobial activities of the synthesized compounds were examined against two types of bacteria and two types of fungi. Part 3: In this part, comparative study between the reactivity of Z- and E- isomers of 2-benzamido-3-phenylacrylohydrazide towards some carbon electrophiles wa