Comparison between Antimicrobial Minimal Biofilm Eradication Concentration and Minimal Inhibitory Concentration in Clinical Isolates in Device Related Infections

Abstract

Medical devices associated infections continue to be a significant source of morbidity and mortality in patients requiring devices and increase medical expenses by prolonging hospitalization. These infections are most commonly caused by biofilm producing organisms. Cells in biofilm display phenotypic traits that are dramatically different from those of their free-floating (planktonic) counterparts and are resistant to antimicrobial agents. Consequently, biofilm-related infections are inherently challenging to treat and difficult to be fully eradicated with normal treatment regimens. The objectives of the present work are to study bacterial biofilm formation in three common medical devices associated infections; (CLABSI, CAUTI and VAP) and comparing antibiotic susceptibility of sessile cells (MBEC) and their planktonic counterpart (MIC) for biofilm forming bacteria. This study was conducted on 90 patients divided into three groups. Group I 30 patients with central venous catheters, Group II 30 patients with urinary catheters and Group III 30 mechanically ventilated patients.