STUDIES ON SCHISTOSOMIASIS VACCINES: HUMAN T & B CELL RESPONSES TO IMMUNOPROTECTIVE APICAL MEMBRANE ANTIGENS FROM ADULT SCHISTOSOMA MANSONI WORMS
Sahar mahmoud Selim;
Abstract
Extraction, fraciionation :md elution of adlut S, numosni worm surfnce antigens '
revealed three well-defined bands in the area 42. The SMI' molecules of 45,42 and
40 KUa clicitC!i lymphoproliferation and/or lFN-y, IL-4 or IL-10 production from PBMC of 0 -• lOll% of donors suggesting that these molecules elicit cell-mediated immunity. While all donors showed detectable humoral responses to SMP by
ELISA, rccoguition of Area 42 antigens by Western blotting was restricted to only
2/22 donors iuriicating that these antigens do not clicitstrong humoral immunity.
revealed three well-defined bands in the area 42. The SMI' molecules of 45,42 and
40 KUa clicitC!i lymphoproliferation and/or lFN-y, IL-4 or IL-10 production from PBMC of 0 -• lOll% of donors suggesting that these molecules elicit cell-mediated immunity. While all donors showed detectable humoral responses to SMP by
ELISA, rccoguition of Area 42 antigens by Western blotting was restricted to only
2/22 donors iuriicating that these antigens do not clicitstrong humoral immunity.
Other data
| Title | STUDIES ON SCHISTOSOMIASIS VACCINES: HUMAN T & B CELL RESPONSES TO IMMUNOPROTECTIVE APICAL MEMBRANE ANTIGENS FROM ADULT SCHISTOSOMA MANSONI WORMS | Other Titles | دراسة عن لقاح للبلهارسيا : إستجابة خلايا ( ت و ب ) في الإنسان والتأثير المناعي الوقائي لأنتيجينات غلاف ديدان البلهارسيا المعوية البالغة | Authors | Sahar mahmoud Selim | Keywords | (.Schistosoma u:ansoni, surface membrane proteins (SMP), SDS--PAGE, protein elution, PBMC proliferation, Capture ELISA, IL-2, IL-4, IL-10, lFN- y, ELISA, Western blotting) | Issue Date | 2002 |
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