Synthesis and Reactions of Some New Heterocyclic Compounds Containing N and/or S of Expected Biological Activities

Abstract

This work has been carried out to investigate the chemical reactivity and synthetic potentiality of 2-thioxohydropyridines 6a-c via their reactions with several active halogen-containing compounds to afford the corres­ ponding 2-alkylthiopyridines in some cases and thieno [2, 3-b] pyridines in most cases. Thieno [2, 3-b] pyridine-2-carbohydrazides obtained through the reactions of 2-ethoxycarbonylthienopyridines with hydrazine hydrate which in tum, used to obtain the corresponding pyrimidinones and oxadiazoles. 3-Aminopyrazolopyridines obtained via the reactions of 6a-c with hydrazine hydrate and the diazonium salt of 6a prepared and coupled with several active-hydrogen contammg reagents to give the corresponding triazines. Structures of all newly synthesized heterocyclic compounds were established by considering the data of both spectroscopic and elemental analyses.