A CLINICAL AND HISTOLOGICAL EVALUATION OF LOCAL VERAPAMIL HYDROCHLORIDE INJECTION IN THE PREVENTION OF KELOID RECURRENCE AFTER EXCISION
Ehab Zaky Ahmed Azzam;
Abstract
Keloids occur as the result of an exaggerated wound healing of the skin following various types of injury. In addition to presenting a cosmetic concern, keloids may be pruritic and restrict the range of motion. Certain patients and certain wounds are at higher risk for keloid formation. The cause of keloids is unknown. Several theories have been proposed, though none has been proven.
Scars are extremely difficult to treat. Multiple treatments have been advocated in the past with varying degrees of success. Keloids have been shown to respond to pressure therapy, intralesional steroids, systemic chemotherapy, radiation, topical silicone, retinoic acid and laser treatment. But until now there is no universally accepted treatment modality resulting in permanent keloid ablation.
The aim of this work was to assess the efficacy oflocal injection of verapamil hydrochloride, a calcium antagonist drug, on recurrence of surgically excised keloidal scars.
This study included 40 patients divided into two equal groups of
20 patients. Patients were matched for sex, age, cause and site of the lesion.
Group I : Included 20 patients who were treated by surgical excision, direct closure and immediate and late post-operative intrascar verapamil hydrochloride injections at timed intervals and were histologically subdivided into group Ia
Scars are extremely difficult to treat. Multiple treatments have been advocated in the past with varying degrees of success. Keloids have been shown to respond to pressure therapy, intralesional steroids, systemic chemotherapy, radiation, topical silicone, retinoic acid and laser treatment. But until now there is no universally accepted treatment modality resulting in permanent keloid ablation.
The aim of this work was to assess the efficacy oflocal injection of verapamil hydrochloride, a calcium antagonist drug, on recurrence of surgically excised keloidal scars.
This study included 40 patients divided into two equal groups of
20 patients. Patients were matched for sex, age, cause and site of the lesion.
Group I : Included 20 patients who were treated by surgical excision, direct closure and immediate and late post-operative intrascar verapamil hydrochloride injections at timed intervals and were histologically subdivided into group Ia
Other data
| Title | A CLINICAL AND HISTOLOGICAL EVALUATION OF LOCAL VERAPAMIL HYDROCHLORIDE INJECTION IN THE PREVENTION OF KELOID RECURRENCE AFTER EXCISION | Other Titles | تقييم اكلينيكى وهستولوجى لاثر الحقن الموضعى لمادة هيدروكلوريد الفيراباميل فى منع ارتداد الندبات التغلظية المخلبية بعد استئصالها | Authors | Ehab Zaky Ahmed Azzam | Issue Date | 2005 |
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