Fibrogenic activity in arteritis• versus atherosclerosis
Sayed Abd ELAzim Mahmoud Hekal;
Abstract
Recent investigations proved high content of collagen in arterial wall of diseased vessels. This phenomenon paved the way for assessment of fibro genic activity in pathogenesis of arterial diseases. Increased deposition of connective tissue components characterizes a broad spectrum of acute and chronic inflammatory diseases.
Increased amount of type Ill collagen which is widely distributed in con
nective tissue and in large arteries are deposited in tissues in early fibrosis.
Procollagen III peptide is an extension peptide released during the bio
sy,nthesis of collagen type III.
Recent studies have shown that radio- immunoassay estimation for pro
collagen III peptide levels may represent a reliable biochemical marker for assessment of fibrogenic activity in diseased organs.
Fibronectin plays an important role in the pathogenesis of fibrosis. Fib
• ronectin accumulation in granulation tissues occur prior to collagen deposi
tion.
The aim of this work is to evaluate the significance of estimation of
>CIII111\'rl'C(lllagen [\1\'ertide :md \'I:J!'m:J fthl'llfllill :1;. mdic:110r;. fc'l the ;1;.
sessment of fibrogenic activity in arteritis and atherosclerosis.
Increased amount of type Ill collagen which is widely distributed in con
nective tissue and in large arteries are deposited in tissues in early fibrosis.
Procollagen III peptide is an extension peptide released during the bio
sy,nthesis of collagen type III.
Recent studies have shown that radio- immunoassay estimation for pro
collagen III peptide levels may represent a reliable biochemical marker for assessment of fibrogenic activity in diseased organs.
Fibronectin plays an important role in the pathogenesis of fibrosis. Fib
• ronectin accumulation in granulation tissues occur prior to collagen deposi
tion.
The aim of this work is to evaluate the significance of estimation of
>CIII111\'rl'C(lllagen [\1\'ertide :md \'I:J!'m:J fthl'llfllill :1;. mdic:110r;. fc'l the ;1;.
sessment of fibrogenic activity in arteritis and atherosclerosis.
Other data
| Title | Fibrogenic activity in arteritis• versus atherosclerosis | Other Titles | النشاط التليفى فى التهابات الشراسسن مقابل تصلب الشرايين | Authors | Sayed Abd ELAzim Mahmoud Hekal | Issue Date | 1994 |
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