THE IMPLICATION OF THE PRESENCE OF OTHER DIABETES-ASSOCIATED AUTOIMMUNE DISORDERS ON THE DISEASE OUTCOME
Mai Mahmoud El Afifi Mahmoud;
Abstract
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in pediatric patients. The incidence of T1DM among children is rising worldwide. The overall annual increase is estimated at 3% with approximately 70,000 children worldwide expected to develop T1DM every year (IDF, 2013).
Patients with T1DM are at high risk of developing other autoimmune diseases, such as autoimmune thyroiditis (AIT) and celiac disease (CD) Moreover, T1DM can lead to numerous complications in pediatric patients. (Al-Agha et al, 2015)
The major effect of intensive islet-cell-specific autoimmunityseems to accelerate target organ destruction, resulting in rapid progression to clinical diabetes and leading to total β-cell destruction after the diagnosis.(Sabbah et al, 1999)
Since both T1DM and CD show the same genetic background and an abnormal small intestinal immune response with inflammation and a variable grade of enteropathy, serological screening for CD should be performed in all T1DM patients by means of antibodies to tissue transglutaminase at T1DM onset.(Volta et al., 2011)
The study aimed to co-relate the presence of Anti-insulin Antibody and / or Anti-tissue Transglutaminase Antibody in type 1 diabetic patients regularly attending the pediatric diabetes clinic at Ain Shams University with the short and long term complications.
Patients with T1DM are at high risk of developing other autoimmune diseases, such as autoimmune thyroiditis (AIT) and celiac disease (CD) Moreover, T1DM can lead to numerous complications in pediatric patients. (Al-Agha et al, 2015)
The major effect of intensive islet-cell-specific autoimmunityseems to accelerate target organ destruction, resulting in rapid progression to clinical diabetes and leading to total β-cell destruction after the diagnosis.(Sabbah et al, 1999)
Since both T1DM and CD show the same genetic background and an abnormal small intestinal immune response with inflammation and a variable grade of enteropathy, serological screening for CD should be performed in all T1DM patients by means of antibodies to tissue transglutaminase at T1DM onset.(Volta et al., 2011)
The study aimed to co-relate the presence of Anti-insulin Antibody and / or Anti-tissue Transglutaminase Antibody in type 1 diabetic patients regularly attending the pediatric diabetes clinic at Ain Shams University with the short and long term complications.
Other data
| Title | THE IMPLICATION OF THE PRESENCE OF OTHER DIABETES-ASSOCIATED AUTOIMMUNE DISORDERS ON THE DISEASE OUTCOME | Other Titles | الآثار المترتبة على وجود اضطرابات المناعة الذاتية المصاحبة لمرض السكرى | Authors | Mai Mahmoud El Afifi Mahmoud | Issue Date | 2015 |
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