The role of caffeic acid in modulating miRNA expression related to diabetic nephropathy in rats

Abstract

The role of caffeic acid in modulating miRNA expression related to diabetic nephropathy in rats. Aya Shaaban Ragheb Shaaban, Biochemistry department, Faculty of Science, Ain Shams University. Diabetic Nephropathy is considered the most common cause of end-stage renal disease (ESRD) around the world that accounts for the high rate of mortality in diabetic patients. However persistent microalbuminuria was the most known biomarker in diabetic nephropathy, there are some limitations in using albuminuria as a marker of diabetic nephropathy (DN) therefore, it became necessary to find alternative biomarkers that help in diagnosis of DN earlier and identify its progression risk. MicroRNA profiling is a promising strategy for diagnosis of diabetic nephropathy. The potential of miRNAs to be biomarkers for kidney diseases has been investigated. Several miRNAs have been reported to have functions related to DN.