Detection of Human Metapneumo Virus in Egyptian Children with Acute Respiratory Illness
Samar Abdel Hady Mohammed Ali;
Abstract
SUMMARY
A
cute respiratory tract infections are (ARI) leading causes of morbidity and mortality worldwide. Of the 10 million deaths of children less than 5 years of age throughout the world, 1.9 million children died from acute lower respiratory tract infections (ALRI) in the year 2000.
Human Metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001in Netherland. It is member of the paramyxoviridae family which also includes respiratory syncytial virus (RSV), measles virus, and mumps virus.
Like other common human respiratory viruses, HMPV is associated with upper respiratory tract infection (URTI), as well as lower respiratory tract infection (LTRI).
This cross sectional study provides some information about the burden of HMPV infections in a group of Egyptian children less than 5 years old from December 2013 to March 2014. The study included 120 infants and children with acute respiratory tract illness; 72 outpatients and 48 inpatients.
Detailed history, stressing on symptoms of presence of any chronic illness, type of feeding, social class, residence, gestational age, exposure to environmental smokes were taken. Full clinical examination was done for every patient with special emphasis on vital data: (pulse, temperature and respiratory rate) and thorough chest examination. Nasopharyngeal swabs were done for them and RT-PCR was done for HMPV.
The age of the studied patients ranged from 1.2 months to 60 months with mean age 14.3 ± 14.8 months, 62.5%were males, 37.5% were females, 33.3% were from rural areas, 66.7% were from urban areas, 10% were preterm,15.8% were artificially fed, 55.8% were breast fed and 55% of patients exposed to 2nd hand smoking. Three patients were known asthmatic, 2 patients had croup, one patient had acute otitis media and one had active rickets.
All of the studied patients had upper respiratory tract coryza (100%) and 25.8% had hoarseness of voice.
Symptoms of lower respiratory tract infection like dyspnea, difficult feeding and grunting were found in 43.3%, 32.5% and 5% respectively.
GIT symptoms like vomiting and diarrhea were found in 10.8% of studied children.
The most prevalent signs were wheezes and crepitation (83.3% and 75.5% respectively).
Chest X- Ray was performed to all patients, 45% had pneumonia and 55% had bronchiolitis.
Complete CBC was done to all patients, 45% were anemic, 29% had neutrophilia, 50.8% had lymphocytosis and 23% were CRP positive.
Twenty eight percent of samples were collected in December, 29.2% were collected in January, 29.2% were collected in February and 13.3% were collected in March.
A
cute respiratory tract infections are (ARI) leading causes of morbidity and mortality worldwide. Of the 10 million deaths of children less than 5 years of age throughout the world, 1.9 million children died from acute lower respiratory tract infections (ALRI) in the year 2000.
Human Metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001in Netherland. It is member of the paramyxoviridae family which also includes respiratory syncytial virus (RSV), measles virus, and mumps virus.
Like other common human respiratory viruses, HMPV is associated with upper respiratory tract infection (URTI), as well as lower respiratory tract infection (LTRI).
This cross sectional study provides some information about the burden of HMPV infections in a group of Egyptian children less than 5 years old from December 2013 to March 2014. The study included 120 infants and children with acute respiratory tract illness; 72 outpatients and 48 inpatients.
Detailed history, stressing on symptoms of presence of any chronic illness, type of feeding, social class, residence, gestational age, exposure to environmental smokes were taken. Full clinical examination was done for every patient with special emphasis on vital data: (pulse, temperature and respiratory rate) and thorough chest examination. Nasopharyngeal swabs were done for them and RT-PCR was done for HMPV.
The age of the studied patients ranged from 1.2 months to 60 months with mean age 14.3 ± 14.8 months, 62.5%were males, 37.5% were females, 33.3% were from rural areas, 66.7% were from urban areas, 10% were preterm,15.8% were artificially fed, 55.8% were breast fed and 55% of patients exposed to 2nd hand smoking. Three patients were known asthmatic, 2 patients had croup, one patient had acute otitis media and one had active rickets.
All of the studied patients had upper respiratory tract coryza (100%) and 25.8% had hoarseness of voice.
Symptoms of lower respiratory tract infection like dyspnea, difficult feeding and grunting were found in 43.3%, 32.5% and 5% respectively.
GIT symptoms like vomiting and diarrhea were found in 10.8% of studied children.
The most prevalent signs were wheezes and crepitation (83.3% and 75.5% respectively).
Chest X- Ray was performed to all patients, 45% had pneumonia and 55% had bronchiolitis.
Complete CBC was done to all patients, 45% were anemic, 29% had neutrophilia, 50.8% had lymphocytosis and 23% were CRP positive.
Twenty eight percent of samples were collected in December, 29.2% were collected in January, 29.2% were collected in February and 13.3% were collected in March.
Other data
| Title | Detection of Human Metapneumo Virus in Egyptian Children with Acute Respiratory Illness | Other Titles | الكشف عن الاصابه بالميتانيموفيروس البشرى عند الاطفال المصريين المصابين بالتهاب الجهاز التنفسي الحاد | Authors | Samar Abdel Hady Mohammed Ali | Issue Date | 2015 |
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