Evaluation of Branched-chain Amino Acids in Autism Spectrum Disorder with Epilepsy
Ahmed Mohamed Mohamed Ezzat Elwan;
Abstract
SUMMARY
T
he autism spectrum disorder (ASD) describes a range of conditions classified as neurodevelopmental disorders in the fifth revision of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5). These disorders are characterized by social deficits and communication difficulties, stereotyped or repetitive behaviors and interests, sensory issues, and in some cases cognitive delays.
Epilepsy prevalence estimates in persons with ASD have ranged from 5% to 46% which is higher than normal population. The overlapping prevalence suggests that epilepsy and ASD share at least some common biological mechanisms.
The three proteinogenic BCAAs (leucine, isoleucine and valine) are among the nine essential amino acids for humans, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. Although a substantial fraction of autism may be highly heritable, the specific genetic causes remain obscure in the majority of cases. Experiments have identified a Mendelian form of autism with comorbid intellectual disability (ID) and epilepsy that is associated with low plasma BCAAs.
T
he autism spectrum disorder (ASD) describes a range of conditions classified as neurodevelopmental disorders in the fifth revision of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5). These disorders are characterized by social deficits and communication difficulties, stereotyped or repetitive behaviors and interests, sensory issues, and in some cases cognitive delays.
Epilepsy prevalence estimates in persons with ASD have ranged from 5% to 46% which is higher than normal population. The overlapping prevalence suggests that epilepsy and ASD share at least some common biological mechanisms.
The three proteinogenic BCAAs (leucine, isoleucine and valine) are among the nine essential amino acids for humans, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. Although a substantial fraction of autism may be highly heritable, the specific genetic causes remain obscure in the majority of cases. Experiments have identified a Mendelian form of autism with comorbid intellectual disability (ID) and epilepsy that is associated with low plasma BCAAs.
Other data
| Title | Evaluation of Branched-chain Amino Acids in Autism Spectrum Disorder with Epilepsy | Other Titles | تقييم مستوى الأحماض الأمينية متفرعة السلسلة في حالات اضطراب طيف التوحد المصاحب بالصرع | Authors | Ahmed Mohamed Mohamed Ezzat Elwan | Issue Date | 2017 |
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