The Role of Prolactin and Growth Hormones in Psoriatic patients
Abeer Abdel Halim Abdel Hamid;
Abstract
Background; the aetiopathogenesis of psoriasis is still not fully understood. It has been reported that prolactin hormone (PRL) and growth hormone (GH) exert a proliferative effect on . human kertinocytes therefore,they may play an important role in pathogenesis of psoriasis. The aim of our study was to assess the serum prolactin and growth hormones levels in patients with psoriasis.
Methods; serum levels of prolactin and growth hormones were estimated in 60 patients with psoriasis (age:11-77 years with a mean of 42.1 and a SD of15.53 years, sex : 40 males, 20 females )compared with 20 normal control' subjects (age:15-50 years with a mean of 30.54 and a SD of
10.72 years,sex:10 males ,10 females)
Results: the mean serum PRL in psoriatic patients was 210.15 IU/ml while in the normal control subjects it was 17.85 IU/ml. This difference was statistically highly significant (P= 0.0001). The mean serum GH in psoi-iatic patients was 2.43 ng /ml and in normal control subjects it was 2.45 ng I ml . This difference was statistically non significant.
Conclusion: since PRL belongs to the growth hormone family, its raised serum level may have a role in the hyperproliferation of kertinocyte , the .hallmark of psoriasis disease process . In our study •. GH has no role in pathogenesis of psoriasis ,however other studies are recommended to clarify the role of both hormones in the aetiopathogenesis of psoriasis .
Methods; serum levels of prolactin and growth hormones were estimated in 60 patients with psoriasis (age:11-77 years with a mean of 42.1 and a SD of15.53 years, sex : 40 males, 20 females )compared with 20 normal control' subjects (age:15-50 years with a mean of 30.54 and a SD of
10.72 years,sex:10 males ,10 females)
Results: the mean serum PRL in psoriatic patients was 210.15 IU/ml while in the normal control subjects it was 17.85 IU/ml. This difference was statistically highly significant (P= 0.0001). The mean serum GH in psoi-iatic patients was 2.43 ng /ml and in normal control subjects it was 2.45 ng I ml . This difference was statistically non significant.
Conclusion: since PRL belongs to the growth hormone family, its raised serum level may have a role in the hyperproliferation of kertinocyte , the .hallmark of psoriasis disease process . In our study •. GH has no role in pathogenesis of psoriasis ,however other studies are recommended to clarify the role of both hormones in the aetiopathogenesis of psoriasis .
Other data
| Title | The Role of Prolactin and Growth Hormones in Psoriatic patients | Other Titles | دور هرمون البرولاكتين وهرمون النمو في مرض الصدفية | Authors | Abeer Abdel Halim Abdel Hamid | Keywords | .PRL , GH, Psoriasis , pathogenesis | Issue Date | 2001 |
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