Hair and serum zinc and copper among children with bronchial asthma
Manal Mohamed Kamal Hamed;
Abstract
T
hiscase control study aimed tostudy the inter-relationships between childhood asthma clinical and functional grading and degree of control and both hair and serum zinc, copper together with growth status in children with bronchialasthma.The current study suggested that low serum and hair of both zinc and copper trace elements have a role in childhood asthma. The current study measured the levels of hair and serum Zinc and Copper to assess their role in asthma severity and control according to GINA classification and spirometric pulmonary function test.
This work was conducted on 50 asthmatic patients from those regularly attending the Pediatric's Chest Clinic, Ain Shams University. Fifty age and sex matched non-asthmatic non-atopic healthy children were recruited as a control group.
The age of asthmatic children included in the study ranged between 6 to 16 years old with mean age (9.0 ± 2.7) years. They were 32 (64%) males and 18 (36%) females with male to female ratio 1.7: 1. While the control group included 31 (62%) males and 19 (38%) females with male to female ratio 1.6:1, their age ranged from 6 to 13 years old with mean age (8.8±2.1) years.
The asthmatic patients were further subdivided according to asthma severity at presentation (GINA,2008) into mild to moderate persistent (n=35) and severe persistent (n=15), According to asthma control (GINA, 2012) during the past three monthsinto Controlled (n=36) 72%, they were 21 males (58.3%) and 15 females (41.7%) and uncontrolled (n=14) 28%, they were 11 males (78.6) and 3 females (21.4%).
As regards, serum zinc levels there is no significant difference among patient group when compared to healthy control group (93.33±24.17ug/dl vs. 100.51±19.16 ug/dl, p=0.52). Also there is no significant difference among patients with severe persistent asthma when compared to patients with mild to moderate persistent asthma (86.09±25.27ug/dlvs. 96.89±20.73 ug/dl, p=0.221).However, hair zinc were significantly lower among patient group in comparison to healthy control (110.64 ± 79.31ug/g vs. 169.24 ± 86.77ug/g, p=0.001), also it was significantly lower among patients with severe persistent asthma in comparison to patients with mild to moderate persistent asthma (57.8 ± 18.9ug/g vs. 133.29 ± 84.61ug/g, p=0.001),
There were significant positive correlations between hair zinc and each of FEV1 (r=0.362, p=0.010), and FEV1/FVC% (r=0.334, p=0.018). While there were significant negative correlation between hair zinc and eosinophils (r= - 279, p=0.050) but there were no correlations between serum zinc with other parameters.
hiscase control study aimed tostudy the inter-relationships between childhood asthma clinical and functional grading and degree of control and both hair and serum zinc, copper together with growth status in children with bronchialasthma.The current study suggested that low serum and hair of both zinc and copper trace elements have a role in childhood asthma. The current study measured the levels of hair and serum Zinc and Copper to assess their role in asthma severity and control according to GINA classification and spirometric pulmonary function test.
This work was conducted on 50 asthmatic patients from those regularly attending the Pediatric's Chest Clinic, Ain Shams University. Fifty age and sex matched non-asthmatic non-atopic healthy children were recruited as a control group.
The age of asthmatic children included in the study ranged between 6 to 16 years old with mean age (9.0 ± 2.7) years. They were 32 (64%) males and 18 (36%) females with male to female ratio 1.7: 1. While the control group included 31 (62%) males and 19 (38%) females with male to female ratio 1.6:1, their age ranged from 6 to 13 years old with mean age (8.8±2.1) years.
The asthmatic patients were further subdivided according to asthma severity at presentation (GINA,2008) into mild to moderate persistent (n=35) and severe persistent (n=15), According to asthma control (GINA, 2012) during the past three monthsinto Controlled (n=36) 72%, they were 21 males (58.3%) and 15 females (41.7%) and uncontrolled (n=14) 28%, they were 11 males (78.6) and 3 females (21.4%).
As regards, serum zinc levels there is no significant difference among patient group when compared to healthy control group (93.33±24.17ug/dl vs. 100.51±19.16 ug/dl, p=0.52). Also there is no significant difference among patients with severe persistent asthma when compared to patients with mild to moderate persistent asthma (86.09±25.27ug/dlvs. 96.89±20.73 ug/dl, p=0.221).However, hair zinc were significantly lower among patient group in comparison to healthy control (110.64 ± 79.31ug/g vs. 169.24 ± 86.77ug/g, p=0.001), also it was significantly lower among patients with severe persistent asthma in comparison to patients with mild to moderate persistent asthma (57.8 ± 18.9ug/g vs. 133.29 ± 84.61ug/g, p=0.001),
There were significant positive correlations between hair zinc and each of FEV1 (r=0.362, p=0.010), and FEV1/FVC% (r=0.334, p=0.018). While there were significant negative correlation between hair zinc and eosinophils (r= - 279, p=0.050) but there were no correlations between serum zinc with other parameters.
Other data
| Title | Hair and serum zinc and copper among children with bronchial asthma | Other Titles | دراسة الزنك والنحاس فى مصل وشعر الأطفال الذين يعانون من الربو الشعبى | Authors | Manal Mohamed Kamal Hamed | Issue Date | 2014 |
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