Screening of Hepatopulmonary Syndrome and Portopulmonary Hypertension in Cholestatic Patients versus Non Cholestatic Patients

Abstract

SUMMARY H epatopulmonary syndrome (HPS) is defined as a clinical triad characterised by an oxygenation defect induced by the presence of pulmonary vasodilation observed in patients with liver disease or portal hypertension. Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) associated with portal hypertension, whether or not portal hypertension is secondary to an underlying liver disease. Aim of this study is to assess the screening of hepatopulmonary syndrome and portopulmonary hypertension in cholestatic patients versus non cholestatic patients. The current cross-sectional study was conducted on 25 cholestatic patients and 25 non cholestatic patients at the pediatric Hepatology Clinic, Faculty of Medicine Ain Shams University and Dr Yassin Abd El Ghaffar charity center for liver disease research. All patients were subjected to detailed medical history, throrough clinical examination, laboratory investigations included Complete blood count, liver function tests, Coagulation profile and oxygen saturation test, blood gases, pulmonary function tests, 12 leads ECG, abdominal ultrasonography, conventional 2D echocardio