Role of CD73 positive cells on progression of GVHD in allogeneic bone marrow transplantation
Rana Zakariya Abass Selim;
Abstract
Over the past 40 years, bone marrow and hematopoietic stem cell transplantation have been used with increasing frequency to treat numerous malignant and nonmalignant diseases.
Although; marked improvements in survival rate following allogeneic HSCT was achieved, graft versus host disease (GVHD) remains the major cause of morbidity and mortality associated with allogeneic transplantation and stands as a significant barrier to this therapy.
Graft versus host disease (GVHD) is an immune driven disorder where donor T cells react and proliferate in response to host antigens leading to an immune reaction that can affect several target organs including liver, skin, and the gastrointestinal tract. Rates of GVHD vary from (30-40%) in transplant from related donors to (60-80%) in transplant from unrelated donors.
Some reports have been done discussing the role of adenosine-tri phosphate (ATP) as an endogenous dangerous signal evoking systemic inflammatory response enhancing GVHD and affecting tumor growth and spread.
Recent murine studies using CD73-deficient mice have shown that CD73-generated adenosine can be manipulated to influence both the severity of GVHD and the strength of the GVL effect.
A prospective study was held at Ain Shams University BMT unit with recruitment of 30 donors as control and30 patients who were eligible for allo-HSCT for diverse benign and malignant hematological disorders. All of these patients had fully matched donors except for one patient who received haplotype transplants from her mother.
Of these patients, 19 were males (63.3%) and 11 were females (36.7%). Their age ranged from 16-55 years old, whereas 22 donors (73.3%) were males and 8 were females (26.7%) and their age ranged from 16-65 years old.
Enrolled cases have different diagnosis including: 13 cases with AML, six cases with ALL, six patients had aplastic anemia, two patients had MDS, another two patients diagnosed with NHL, and finally the last case had CML.
All of the cases were subjected to routine pre-transplant history taking, thorough clinical examination and different investigations as complete blood picture, liver profile, kidney
Although; marked improvements in survival rate following allogeneic HSCT was achieved, graft versus host disease (GVHD) remains the major cause of morbidity and mortality associated with allogeneic transplantation and stands as a significant barrier to this therapy.
Graft versus host disease (GVHD) is an immune driven disorder where donor T cells react and proliferate in response to host antigens leading to an immune reaction that can affect several target organs including liver, skin, and the gastrointestinal tract. Rates of GVHD vary from (30-40%) in transplant from related donors to (60-80%) in transplant from unrelated donors.
Some reports have been done discussing the role of adenosine-tri phosphate (ATP) as an endogenous dangerous signal evoking systemic inflammatory response enhancing GVHD and affecting tumor growth and spread.
Recent murine studies using CD73-deficient mice have shown that CD73-generated adenosine can be manipulated to influence both the severity of GVHD and the strength of the GVL effect.
A prospective study was held at Ain Shams University BMT unit with recruitment of 30 donors as control and30 patients who were eligible for allo-HSCT for diverse benign and malignant hematological disorders. All of these patients had fully matched donors except for one patient who received haplotype transplants from her mother.
Of these patients, 19 were males (63.3%) and 11 were females (36.7%). Their age ranged from 16-55 years old, whereas 22 donors (73.3%) were males and 8 were females (26.7%) and their age ranged from 16-65 years old.
Enrolled cases have different diagnosis including: 13 cases with AML, six cases with ALL, six patients had aplastic anemia, two patients had MDS, another two patients diagnosed with NHL, and finally the last case had CML.
All of the cases were subjected to routine pre-transplant history taking, thorough clinical examination and different investigations as complete blood picture, liver profile, kidney
Other data
| Title | Role of CD73 positive cells on progression of GVHD in allogeneic bone marrow transplantation | Authors | Rana Zakariya Abass Selim | Issue Date | 2018 |
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