Comparative study between the Efficacy of Pyridoxine Combined Cyclizine and Metoclopramide in the Management of Nausea and Vomiting with Pregnancy

Abstract

Nausea and vomiting of pregnancy (NVP) is a debilitating condition affecting many pregnant women. Up to 90% of pregnant women will experience NVP of varying severity, with symptoms generally starting around 4–9 weeks of gestation, peaking around the 7th to 12th week, and subsiding by the 16th week. NVP symptoms will appear prior to ten weeks of gestation; women who experience NVP symptoms for the first time after 10 weeks, may be experiencing nausea and vomiting due to other medical conditions. The diagnosis of NVP is clinical in nature, and although other causes of persistent nausea, retching and/or vomiting are rarely encountered, failure to distinguish them from NVP can result in serious complications. Generally it has been observed that women who experience NVP have better pregnancy outcomes than those who don’t, and women who use antiemetics appear to have better pregnancy outcomes than women with NVP who don’t receive treatment. One explanation for this is that women who use antiemetics, tend to experience severe NVP which may be associated with a more robust placenta secr