Assessment of CD4+CD28null T- Lymphocytes in Pediatric Patients with Sickle Cell Disease
Aya Sayed Saad Sayed ElBalasy;
Abstract
SUMMARY
S
ickle cell disease (SCD) is one of the most common severe monogenic disorders in the world. Hemoglobin polymerization, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anemia, hemolysis, and vasculopathy has been established. Patients with SCD are known to have altered immune systems. CD4+ T lymphocyte influence the functions of virtually all other cells of the immune system, including other T cells, B cells, macrophages and natural killer cells. CD4+CD28null T-cells are a subset of long-lived directly cytotoxic CD4+ T lymphocytes that have pro- inflammatory functions characterized by the production of high levels of interferon-gamma.The proinflammatory and cytotoxic capacities of these cells indicate an involvement in progression and maintenance of chronic immune-mediated disease.
Therefore, we assessed the percentage of CD4+
S
ickle cell disease (SCD) is one of the most common severe monogenic disorders in the world. Hemoglobin polymerization, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anemia, hemolysis, and vasculopathy has been established. Patients with SCD are known to have altered immune systems. CD4+ T lymphocyte influence the functions of virtually all other cells of the immune system, including other T cells, B cells, macrophages and natural killer cells. CD4+CD28null T-cells are a subset of long-lived directly cytotoxic CD4+ T lymphocytes that have pro- inflammatory functions characterized by the production of high levels of interferon-gamma.The proinflammatory and cytotoxic capacities of these cells indicate an involvement in progression and maintenance of chronic immune-mediated disease.
Therefore, we assessed the percentage of CD4+
Other data
| Title | Assessment of CD4+CD28null T- Lymphocytes in Pediatric Patients with Sickle Cell Disease | Other Titles | تقييم الخلايا الليمفاوية التائية سي دي 4 موجب سي دي 28 سالب في الأطفال المصابين بالأنيميا المنجلية | Authors | Aya Sayed Saad Sayed ElBalasy | Issue Date | 2017 |
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