Development of Chitosan Films Capable of Sustained-Release of Heparin and Their Applications in Biocompatible Sensors

Abstract

Development of Chitosan Films Capable of Sustained-Release of Heparin and Their Applications in Biocompatible Sensors The studies presented in this dissertation include development of chitosan films capable of sustained release of anticoagulant heparin and applying these films to enhance the biocompatibility of sodium selective electrode. Synthesis and characterizations of chitosan-CuO nanoparticle and heparin loaded chitosan-CuO nanoparticle composite membranes were accomplished. Heparin sensor was used to detect the amount of heparin released from heparin loaded chitosan CuO nanoparticle membranes. Heparin loaded chitosan CuO nanoparticle membranes were shown to be capable of sustained release of heparin up to 72 Hr. Chitosan –CuONPs and chitosan-CuONPs loaded with heparin were introduced to enhance the biocompatibility of sodium selective electrodes based on the highly thrombogenic poly (vinyl chloride).