Effect of Autologous Fibrin Gel and Platelet Rich Plasma activated by Ozone versus those activated by Calcium Chloride on wound healing and prevention of infection in High Risk Cesarean Sections: Randomized Controlled Study

Abstract

Cesarean delivery, one of the most common major surgical procedures performed worldwide used for 15% of births around the world and it continues to increase. It is an important contributor to surgical site complications such as infection, hematoma, seroma, dehiscence, and pain. The overall rate ofpost-CS complications isdecreasing owing toimprovedsurgicaltechniques and use ofantibioticprophylaxisandregionalanesthesia. Nevertheless, ascomparedtovaginal deliveries,CSis still associatedwith a higher riskofimmediate and long-term maternalmorbidityandmortalitythanvaginaldelivery. 2) Rationale: Several risk factors affect the wound healing process in cesarean sections, such as: (1)chronic systemic disease (diabetes, and immune deficiencies), (3) obesity, (4) previous incision, (5) corticosteroid therapy. Post CS wound infection is a commonly encountered complication. Its incidence ranges between 3% and 15%. When antibiotic prophylaxis is administered, this rate drops to <2%. Although the causes of wound infection following cesarean section are globally similar, it has a bothersome occurrence despite the administration of potent antibiotics and observation of aseptic techniques.