Effect of Danazol on Expression of Endometrial αvβ3 Integrin in Patients with Recurrent IVF-ET Failures: A Randomized Controlled trial
Hamed Abdelsadek Aziz Hamed Al-Aarag;
Abstract
An infertility diagnosis can have grave psychological and physiological implications for both members of a couple.
According to guidelines from the National Institute for Health and Clinical Excellence (NICE, 2004), failure to conceive after a period of 2 years should be defined as infertility. Couples can be referred for investigations after 1 year.
Unexplained infertility refers to the absence of a definable cause for a couple’s failure to achieve pregnancy after 12 months of attempting conception despite a thorough evaluation. Despite improved diagnostic techniques, the average incidence of unexplained infertility has been reported to be approximately 15%. A large number of human pregnancies fail during the implantation stage because the uterine endometrium is unreceptive to the implanting embryo.
Embryo implantation represents the most critical step of the reproductive process in many species. Successful implantation requires a receptive endometrium, a normal and functional embryo at the blastocyst developmental stage and a synchronized dialogue between maternal and embryonic tissues.
The endometrium is receptive to blastocyst implantation during a spatially and temporally restricted window, called the implantation window. In humans, this period begins 6-10 days after the LH surge and lasts~48 hours.
The recent discovery of molecules crucial for successful embryo implantation has offered researchers precious insight into this field. Primary adhesion molecules that are implicated in implantation include selectins, galectins, heparan sulfate proteoglycans, MUC1, integrins, cadherins, etc.
Integrins are a family of cell adhesion molecules that have now been largely accepted as markers of uterine receptivity. Their pattern of expression during the menstrual cycle suggests that integrins may also provide a means to study the factors that regulate the establishment of uterine receptivity in general. Integrins are a family of transmembrane glycoproteins, formed by the association of two different, non-covalently linked, α and β subunits. To date, 18 α and eight β chains have been identified in mammals. When paired, they form 24 distinct integrin heterodimers that differ in their function.
In the human endometrium, αvß3 integrin plays an important role in the implantation process & is a well characterized biomarker of uterine receptivity.
Considering the literature on integrin αvβ3 expression and regulation, this protein represents a promising clinical and research marker of the human embryo implantation process.
This study has focused on endometrial integrins and how to promote its expression. The objective of the study is
According to guidelines from the National Institute for Health and Clinical Excellence (NICE, 2004), failure to conceive after a period of 2 years should be defined as infertility. Couples can be referred for investigations after 1 year.
Unexplained infertility refers to the absence of a definable cause for a couple’s failure to achieve pregnancy after 12 months of attempting conception despite a thorough evaluation. Despite improved diagnostic techniques, the average incidence of unexplained infertility has been reported to be approximately 15%. A large number of human pregnancies fail during the implantation stage because the uterine endometrium is unreceptive to the implanting embryo.
Embryo implantation represents the most critical step of the reproductive process in many species. Successful implantation requires a receptive endometrium, a normal and functional embryo at the blastocyst developmental stage and a synchronized dialogue between maternal and embryonic tissues.
The endometrium is receptive to blastocyst implantation during a spatially and temporally restricted window, called the implantation window. In humans, this period begins 6-10 days after the LH surge and lasts~48 hours.
The recent discovery of molecules crucial for successful embryo implantation has offered researchers precious insight into this field. Primary adhesion molecules that are implicated in implantation include selectins, galectins, heparan sulfate proteoglycans, MUC1, integrins, cadherins, etc.
Integrins are a family of cell adhesion molecules that have now been largely accepted as markers of uterine receptivity. Their pattern of expression during the menstrual cycle suggests that integrins may also provide a means to study the factors that regulate the establishment of uterine receptivity in general. Integrins are a family of transmembrane glycoproteins, formed by the association of two different, non-covalently linked, α and β subunits. To date, 18 α and eight β chains have been identified in mammals. When paired, they form 24 distinct integrin heterodimers that differ in their function.
In the human endometrium, αvß3 integrin plays an important role in the implantation process & is a well characterized biomarker of uterine receptivity.
Considering the literature on integrin αvβ3 expression and regulation, this protein represents a promising clinical and research marker of the human embryo implantation process.
This study has focused on endometrial integrins and how to promote its expression. The objective of the study is
Other data
| Title | Effect of Danazol on Expression of Endometrial αvβ3 Integrin in Patients with Recurrent IVF-ET Failures: A Randomized Controlled trial | Other Titles | تـأثير عقار الدانازول علي التعبير عن الإنـتغرين vβ3α في بـطانة الرحم في المرضي الذين يعانون من الفشل المتكرر لعمليات الحقن المجهري: تجربة عشوائية | Authors | Hamed Abdelsadek Aziz Hamed Al-Aarag | Issue Date | 2017 |
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