The Effect of Simvastatin on BMP-2 Expression in Surgically Created Bony Defect: An Experimental Study
Dina Abd El Aziz Metwally Abdo;
Abstract
This study was conducted to evaluate the effect of locally applied
simvastatin on the expression of BMP-2 in the upper extremity of rabbit
tibia.
Bone morphogenetic protein-2 (BMP-2) is one of the most potent
growth factors targeting bone formation in vivo, which stimulates
osteoblast differentiation and proliferation. The evaluation of the BMP-2
expression is the most adequate way to investigate ability of bone
healing and regeneration. Statins are specific, competitive inhibitors of
3-hydroxy-2-methyl-glutaryl coenzyme A (HMG CoA) reductase. They
are widely used to lower cholesterol, and they provide an important and
effective approach toward the treatment of hyperlipidemia and
arteriosclerosis.
In addition to the cholesterol-lowering effect, statins have a series of
pleiotropic effects. Among these diverse effects, bone anabolism has
been the focus of researchers for more than a decade, due to the
potential clinical applications of statins to treat osteoporosis and other
bone deficiencies. The suggestion that statins can increase bone
formation has provided an exciting new direction for research as well as
providing a greater understanding of the biological importance of
cholesterol synthetic pathways.
Twenty one adult male white New Zealand rabbits were included in
this study. The surgery was conducted under general anesthesia through
simvastatin on the expression of BMP-2 in the upper extremity of rabbit
tibia.
Bone morphogenetic protein-2 (BMP-2) is one of the most potent
growth factors targeting bone formation in vivo, which stimulates
osteoblast differentiation and proliferation. The evaluation of the BMP-2
expression is the most adequate way to investigate ability of bone
healing and regeneration. Statins are specific, competitive inhibitors of
3-hydroxy-2-methyl-glutaryl coenzyme A (HMG CoA) reductase. They
are widely used to lower cholesterol, and they provide an important and
effective approach toward the treatment of hyperlipidemia and
arteriosclerosis.
In addition to the cholesterol-lowering effect, statins have a series of
pleiotropic effects. Among these diverse effects, bone anabolism has
been the focus of researchers for more than a decade, due to the
potential clinical applications of statins to treat osteoporosis and other
bone deficiencies. The suggestion that statins can increase bone
formation has provided an exciting new direction for research as well as
providing a greater understanding of the biological importance of
cholesterol synthetic pathways.
Twenty one adult male white New Zealand rabbits were included in
this study. The surgery was conducted under general anesthesia through
Other data
| Title | The Effect of Simvastatin on BMP-2 Expression in Surgically Created Bony Defect: An Experimental Study | Other Titles | تأثير السيمفاستاتين على بروتين تخلق العظام-٢ (بي إم بي-٢ ) في عيب عظمي خُلق جراحيا : دراسة تجريبية | Authors | Dina Abd El Aziz Metwally Abdo | Issue Date | 2017 |
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