Synthesis of Some New Heterocyclic Systems Bearing 1,2,4-Triazine Moiety And Their Antimicrobial Activities

Abstract

I,2,4-Triazines have been reported as starting material for the building of various heterobicyclic systems and possess important biological, pharmacological and medicinal activities. In continuation to our earlier work in this area, the present study deals the synthesis and chemistry of a series of new heterobicyclic nitrogen compounds starting fi•om 3-amino-5,6-disubstituted-1,2,4-triazines and their evaluated for anti-HIV and anticancer activities to establish a correlation between structure and reactivity.

Thus, some new heterobicyclic nitrogen systems bearing 1,2,4- triazine moiety such as, phthalamide, imidazolone, quinazolinone, pyrimidindiones and 1,2,4-triazines (3-22) have been achieved by treatment of 3-amino-6-methyl-5-styryl-1,2,4- triazines (2a-h) with some cyclic and acyclic oxygen compounds followed by heterocyclization . (Scheme 1-3). Structures of the products have been deduced by elemental analysis and spectral data (UV, IR, 1H NMR & mass). Significant anti­

HIV and anticancer activities were observed in vitro for some members of the series, where compounds 5 and 18 showed a moderate activity (Tables 1,2).