BIOCHEMICAL CHANGES INDUCED BY SILDENAFIL ( VIAGRA) IN DIBETIC RATS
Abeer Adel Awad;
Abstract
Penile erection is a complex neurovascular event involving the interaction of three physiological systems.
1- The central nervous system.
Where the activation of dopamine receptors is associated with the induction of erection.
2- The peripheral nervous system.
In general activation of parasympathetic nervous system is associated with the induction of erection.
3- Penile arterial and smooth muscle.
The relation of penile smooth muscle is mediated mainly by nitric oxide which exerts its action on smooth muscle through activation of soluble guanylyl cyclase (SGC). Activation of SGC catalyses the conversion of guanosine triphosphate GTP to the active cyclic guanosine monophosphate cGMP. The enzyme PDE5 degrades cGMP leading to penile smooth muscle relaxation.
By inhibiting the degradation of cGMP by (PDE5 inhibitors), they prolong the activity of cGMP thus potentiate the erection response.
So the mechanism of erection may be affected by diseases
related to autonomic neurotransmission.
Erectile dysfunction (ED), the persistent inability to achieve or maintain an erection for satisfactory sexual performance, a condition that affects 100 million men world wide, and is associated with adverse effects on quality of life, particularly personal well-being, family and social interrelationships.
1- The central nervous system.
Where the activation of dopamine receptors is associated with the induction of erection.
2- The peripheral nervous system.
In general activation of parasympathetic nervous system is associated with the induction of erection.
3- Penile arterial and smooth muscle.
The relation of penile smooth muscle is mediated mainly by nitric oxide which exerts its action on smooth muscle through activation of soluble guanylyl cyclase (SGC). Activation of SGC catalyses the conversion of guanosine triphosphate GTP to the active cyclic guanosine monophosphate cGMP. The enzyme PDE5 degrades cGMP leading to penile smooth muscle relaxation.
By inhibiting the degradation of cGMP by (PDE5 inhibitors), they prolong the activity of cGMP thus potentiate the erection response.
So the mechanism of erection may be affected by diseases
related to autonomic neurotransmission.
Erectile dysfunction (ED), the persistent inability to achieve or maintain an erection for satisfactory sexual performance, a condition that affects 100 million men world wide, and is associated with adverse effects on quality of life, particularly personal well-being, family and social interrelationships.
Other data
| Title | BIOCHEMICAL CHANGES INDUCED BY SILDENAFIL ( VIAGRA) IN DIBETIC RATS | Other Titles | التغيرات الكيميائية الحيوية المحدثة بالسلدينافيل ( الفياجرا ) فى الجرذان المريضة بالسكرى | Authors | Abeer Adel Awad | Issue Date | 2008 |
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