ASSOCIATION BETTWEEN INTERLEUKIN-6 PROMOTER 174 POLYMORPHISM AND SPONTANEOUS PRETERM LABOR

Abstract

TB continues to be the leading cause of perinatal morbidity & mortality throughout the world. Despite advances in perinatal care, the incidence of PTL has not decreased significantly over the past 40 years. The use of biological markers to enhance the clinical accuracy in predicting PTB has been recently proposed. In this study IL6 gene promotor polymorphism used as a predictive markers for PTL. In this study, a total of 160 pregnant women were included. Patients were divided into 2 groups: Group A: Included Study group (n = 80) Evidence of characteristic established preterm labor; Regular uterine contractions, cervical dilatation more than 4 cm, cervical effacement more than 50%. Group B: Included control group (n = 80) Normal pregnancy without any complications. Gestational age were assessed on the basis of the last normal menstrual period and confirmed by sonographic measurements in the first trimesters.