Non-invasive Methods in Diagnosis of Nonalcoholic Fatty Liver Disease
Mostafa Mahmoud Abdelrazek;
Abstract
Non-alcoholic fatty liver disease (NAFLD) is defined as fatty infiltration within the liver in the absence of other causes of steatosis, such as alcoholic consumption.
In our study 100 patients with fatty liver 50 patients had diabetes, the other 50 patients had no-diabetes were selected from Hepatology and Gastroenterology clinics, Ain Shams University Hospitals and El- Sahel Teaching Hospital to compare between different non-invasive methods in diagnosis of non-alcoholic fatty liver disease.
According to our study we found that:
Sex had no effect on the incidence of non-alcoholic liver disease, yet males had higher values in liver stiffness score and in more advanced fibrosis stages than females without significant difference and this phenomenon may be explained by the protective effect of female sex hormones on the progression of hepatic fibrosis.
Increasing age usually associated with more severe fibrosis, high liver stiffness values and more with diabetic and this may reflect the cumulative sum of metabolic exposures and longer duration of non-alcoholic fatty liver disease in these populations.
BMI and waist circumference are positively related to the presence of non-alcoholic fatty liver disease.
Diabetic patients had higher TG, BMI, blood pressure (SBP&DBP) and low HDL levels than those with non-diabetic, thus presenting a higher metabolic risk factor for non-alcoholic fatty liver disease incidence, so early detection and assessment of fatty liver among diabetics can be potentially preventive of bad prognosis by more frequent monitoring and more strict therapeutic interventions.
Fib-4, Liver stiffness score and NAFLD fibrosis score were higher in patients with advanced fibrosis (> F2) than those with mild to moderate fibrosis (F2or less).
The combination of Fibroscan, Fib-4 and NAFLD fibrosis score provides a valuable non-invasive method in diagnosis of non-alcoholic fatty liver disease, and this can eliminate the need for liver biopsy in patients without clear indication.
In our study 100 patients with fatty liver 50 patients had diabetes, the other 50 patients had no-diabetes were selected from Hepatology and Gastroenterology clinics, Ain Shams University Hospitals and El- Sahel Teaching Hospital to compare between different non-invasive methods in diagnosis of non-alcoholic fatty liver disease.
According to our study we found that:
Sex had no effect on the incidence of non-alcoholic liver disease, yet males had higher values in liver stiffness score and in more advanced fibrosis stages than females without significant difference and this phenomenon may be explained by the protective effect of female sex hormones on the progression of hepatic fibrosis.
Increasing age usually associated with more severe fibrosis, high liver stiffness values and more with diabetic and this may reflect the cumulative sum of metabolic exposures and longer duration of non-alcoholic fatty liver disease in these populations.
BMI and waist circumference are positively related to the presence of non-alcoholic fatty liver disease.
Diabetic patients had higher TG, BMI, blood pressure (SBP&DBP) and low HDL levels than those with non-diabetic, thus presenting a higher metabolic risk factor for non-alcoholic fatty liver disease incidence, so early detection and assessment of fatty liver among diabetics can be potentially preventive of bad prognosis by more frequent monitoring and more strict therapeutic interventions.
Fib-4, Liver stiffness score and NAFLD fibrosis score were higher in patients with advanced fibrosis (> F2) than those with mild to moderate fibrosis (F2or less).
The combination of Fibroscan, Fib-4 and NAFLD fibrosis score provides a valuable non-invasive method in diagnosis of non-alcoholic fatty liver disease, and this can eliminate the need for liver biopsy in patients without clear indication.
Other data
| Title | Non-invasive Methods in Diagnosis of Nonalcoholic Fatty Liver Disease | Other Titles | أساليب غير الغازية في تشخيص مرض الكبد الدهني غير الكحولي | Authors | Mostafa Mahmoud Abdelrazek | Issue Date | 2017 |
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