Evaluation of the effect of omega-3 fatty acids on the induced hepatotoxicity of methotrexate in acute lymphoblastic leukemia children
Reham Kamel Farahat;
Abstract
Background: Previous studies have demonstrated that patients receiving oral methotrexate in maintenance phase of acute lymphoblastic leukemia suffer from many side effects, the most is hepatotoxicity . In the other hand there was different studies demonstrated the protective effect of Omega-3 fatty acids on liver cells .
Objective: To evaluate the protective effect of Omega-3 fatty acids on the induced hepatotoxic effect of oral methotrexate in childhood acute lymphoblastic leukemia .
Methods: A prospective, randomized, open labeled, controlled clinical trial, was conducted on 60 Egyptian children with acute lymphoblastic leukemia in maintenance phase. From June 2012 to March 2014.The patients were included into two groups, group I: 30 patients received oral methotrexate only (20mg/m2), group II: 26 patients received methotrexate (20mg/m2) in combination with omega-3(1000mg/day). Both groups were followed up for six months; data were collected at the beginning of the study and at the end of the study.
Results: At the beginning of the study there was no significant difference between the two groups neither in demographic nor baseline laboratory data, while after six months there was a significant difference (p<0.001) between the two groups regarding signs and symptoms of hepatic toxicity, better compliance and no one of the patients stopped the chemotherapy cycle in second group due to liver toxicity all over the study period. Conclusion: The use of omega-3 fatty acids provides a significant protective effect on liver cells against methotrexate toxic effect upon liver cells. Improvement in quality of life due to absence of liver toxicity which causes fatigue and pain to the patient. The chemotherapy cycle was completed without any interruptions and no signs of hepatic damage was observed. Key words: Acute lumphoblastic leukemia, Methotrexate, Omega-3, Oxidative stress, Malondialdhyde, Clinical pharmacy.
Objective: To evaluate the protective effect of Omega-3 fatty acids on the induced hepatotoxic effect of oral methotrexate in childhood acute lymphoblastic leukemia .
Methods: A prospective, randomized, open labeled, controlled clinical trial, was conducted on 60 Egyptian children with acute lymphoblastic leukemia in maintenance phase. From June 2012 to March 2014.The patients were included into two groups, group I: 30 patients received oral methotrexate only (20mg/m2), group II: 26 patients received methotrexate (20mg/m2) in combination with omega-3(1000mg/day). Both groups were followed up for six months; data were collected at the beginning of the study and at the end of the study.
Results: At the beginning of the study there was no significant difference between the two groups neither in demographic nor baseline laboratory data, while after six months there was a significant difference (p<0.001) between the two groups regarding signs and symptoms of hepatic toxicity, better compliance and no one of the patients stopped the chemotherapy cycle in second group due to liver toxicity all over the study period. Conclusion: The use of omega-3 fatty acids provides a significant protective effect on liver cells against methotrexate toxic effect upon liver cells. Improvement in quality of life due to absence of liver toxicity which causes fatigue and pain to the patient. The chemotherapy cycle was completed without any interruptions and no signs of hepatic damage was observed. Key words: Acute lumphoblastic leukemia, Methotrexate, Omega-3, Oxidative stress, Malondialdhyde, Clinical pharmacy.
Other data
| Title | Evaluation of the effect of omega-3 fatty acids on the induced hepatotoxicity of methotrexate in acute lymphoblastic leukemia children | Other Titles | تقييم تاثير الاحماض الدهنية اوميجا-3علي التسمم الكبدي الناتج من الميثوتركسات في الاطفال المصابين بسرطان الغدد الليمفاوية الحاد | Authors | Reham Kamel Farahat | Issue Date | 2015 |
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