Effect of PleurotusOstreatus on the endothelial dysfunction in ovariectomized- diabetic rats.

Abstract

Diabetes mellitus is a complex of metabolic disease characterized by elevated blood glucose as a result of diminished insulin production, impaired insulin action, or a combination of both, hyperlipidemia, oxidative stress and alterations in coagulation and fibrinolysis leading to impaired endothelial function. Menopause is defined as the permanent cessation of menstruation resulting from loss of ovarian-follicular activity, with a decrease in the levels of estrogens that affecting many tissues of the body. Estrogen deficiency causes endothelial dysfunction which mediated through increasing production of ROS, modification of lipid profile and reduced NO bioavailability which accounts for the impaired endothelium-dependent relaxations. These abnormalities exert pathological impact on endothelial function by attenuating endothelium-mediated vasomotor function, enhanced generation of ROS and impaired fibrinolysis with consequent thrombus formation result in endothelial dysfunction.