STUDY OF SOME ENZYMES AS PREDICTORS FOR THE SEVERITY OF ACUTE CARBON MONOXIDE INTOXICATION
MOHAMED MAHMOUD EL-SEIRAFI;
Abstract
Historical Review
Carbon monoxide (CO) IS a colourless, odourless, tasteless, and non initant gas.OJ Because of these physical properties, CO gives no warning of its presence, hence its description as a silent killer.(2)
It nonnally appears in atmospheric concentration of 0.001% (I0 ppm). However, The normal rate of endogenous CO production in man is 0.42 ml/hr as a result of normal hemoglobin (Hb) catabolic process.(3)
CO was first discovered with the introduction of hydrocarbon fuels which undergo incomplete combustion.<4 J
Napoleon's surgeon; saw soldiers with CO-induced myonecrosis when billeted in huts heated by wood burning stoves.
True incidence of CO p01somng is not known, since non lethal exposures may go untreated or it may has been confused with other diseases as flu-like viral illness and gastroenteritis.
CO poisoning is the most common cause of toxin induced deaths in
··:'!-
the U.S. and Great Britain and may account for as many as 5.000 deaths each year in the U.S., with an additional 10.000 patients seeking medical attention for toxic exposure.<9 10J Mortality rates as high as 31% have been reported in United States (U.S).(ll)
CO poisoning may be deliberate or accidental, in the later case, it may be : acute, subacute, or chronic(IZ,IJ,I 4J
Carbon monoxide (CO) IS a colourless, odourless, tasteless, and non initant gas.OJ Because of these physical properties, CO gives no warning of its presence, hence its description as a silent killer.(2)
It nonnally appears in atmospheric concentration of 0.001% (I0 ppm). However, The normal rate of endogenous CO production in man is 0.42 ml/hr as a result of normal hemoglobin (Hb) catabolic process.(3)
CO was first discovered with the introduction of hydrocarbon fuels which undergo incomplete combustion.<4 J
Napoleon's surgeon; saw soldiers with CO-induced myonecrosis when billeted in huts heated by wood burning stoves.
True incidence of CO p01somng is not known, since non lethal exposures may go untreated or it may has been confused with other diseases as flu-like viral illness and gastroenteritis.
CO poisoning is the most common cause of toxin induced deaths in
··:'!-
the U.S. and Great Britain and may account for as many as 5.000 deaths each year in the U.S., with an additional 10.000 patients seeking medical attention for toxic exposure.<9 10J Mortality rates as high as 31% have been reported in United States (U.S).(ll)
CO poisoning may be deliberate or accidental, in the later case, it may be : acute, subacute, or chronic(IZ,IJ,I 4J
Other data
| Title | STUDY OF SOME ENZYMES AS PREDICTORS FOR THE SEVERITY OF ACUTE CARBON MONOXIDE INTOXICATION | Other Titles | دراسة بعض الانزيمات كمؤشرات لشدة التسمم الحاد بأول اكسيد الكربون | Authors | MOHAMED MAHMOUD EL-SEIRAFI | Issue Date | 2003 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| MOHAMED MAHMOUD EL-SEIRAFI.pdf | 1.43 MB | Adobe PDF | View/Open |
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